I would suggest that you monitor the types of traffic you have on the WAN links and also monitor your throughput to be sure that you are getting the throughput that you need. Your other option would be to install a product such as Citrix. This product has servers that access the applications and files locally to the server and the only thing that travels the Internet links is mouse clicks, keystrokes and screen refreshes. You can also look at a product like Packeteer that will allow you to prioritize your traffic. As for tuning the Microsoft applications, I am not aware of anything internal to the applications that will help. You may also want to check which protocols are loaded at the workstations. You can also increase the buffers in your switches and routers for added benefit.
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