Generally speaking, think of a MAC address like a physical street address and an IP address like a person's name. To get a message to "Brad," for instance, I need more than just the name. I also need a physical street address. Therefore, the ARP process, or MAC address resolution, will always be going on in the background. So if you are trying to keep certain devices off the network, one common method is to block the MAC address at the switch. Locking down the switch will prevent individuals from plugging in an unauthorized device.
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